TARDBP and amyotrophic lateral sclerosis: Furthermore, TDP-43 is identified as a major component of ubiquitinated neuronal inclusions in the cytoplasm, a pathological hallmark of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43 encephalopathy (LATE), a condition with clinical presentation overlapping with Alzheimer’s disease7–11.