Xu et al. found that circRNA-SORE, upregulated in sorafenib-resistant HCC cells, hindered the degradation of Y-box-binding protein 1 (YBX1) by E3 ubiquitin ligase processing factor 19 (PRP19) and prevented nuclear translocation of the carcinogenic protein YBX1. This evidence concerns the gene YBX1 and hepatocellular carcinoma.