SIRT1 and hepatocellular carcinoma: Dong et al. observed that miR-124-3p expression is downregulated in HCC tissues; this downregulation enhanced the dephosphorylation of AKT2 and silent information regulator sirtuin 1 (SIRT1 or sirtuin 1), resulting in decreased downstream forkhead box class O3a (FOXO3a) activity.