HOTAIRM1 and hepatocellular carcinoma: The lncRNA HOTAIRM1, a conserved Hox gene cluster, is significantly upregulated in lenvatinib-resistant HCC; it activates the downstream autophagy-related factor beclin-1 and triggers autophagy to promote lenvatinib resistance through the suppression of miR-34a, a molecular sponge of HOTAIRM1 [157].