Chen et al. reported that the lncRNA NIFK-AS1 is upregulated by METTL3-dependent m6A methylation in HCC, resulting in the downregulation of the drug transporters OATP1B1 and OATP1B3, which are mainly responsible for sorafenib uptake. This evidence concerns the gene SLCO1B3 and hepatocellular carcinoma.