FBXW7 and hepatocellular carcinoma: In addition, miR-25 was highly expressed in HCC tissues, where it negatively regulated the expression of the downstream suppressor gene F-box and WD repeat domain-containing 7 (FBXW7), a component of the SKP1-cullin-1-F-box-protein (SCF) E3 ligase complex involved in autophagy-related ubiquitination.