Chen et al. reported that the lncRNA NIFK-AS1 is upregulated by METTL3-dependent m6A methylation in HCC, resulting in the downregulation of the drug transporters OATP1B1 and OATP1B3, which are mainly responsible for sorafenib uptake. The gene discussed is SLCO1B1; the disease is hepatocellular carcinoma.