The lncRNA LINC01468, significantly upregulated in MAFLD and HCC, disrupts SH2 domain-containing inositol polyphosphate 5-phosphatase-2 (SHIP2) protein stability by modulating Cullin 4A (CUL4A)-mediated ubiquitination; this process activates the PI3K/AKT/mTOR signaling pathway, promoting de novo lipid biosynthesis and sorafenib resistance [96]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.