Lu et al. discovered that HCC exhibit elevated lactylation levels, which promote lactylation at the K76 site of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), enhancing its binding to m6A-modified phosphate carboxykinase 2 (PCK2) and nuclear factor erythroid 2-related factor 2 (NRF2) mRNAs and boosting the antioxidant capacity of HCC cells. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.