KRAS and neoplasm: The recent study by Liang et al. [8] provides crucial mechanistic insight, revealing that sulindac sulfide (SS), the active metabolite of sulindac, restores tumor-suppressive miRNA lethal-7b (Let-7b) to disrupt the Kirsten rat sarcoma viral oncogene homolog (K-Ras)/extracellular signal-regulated kinase (ERK)/lin-28 RNA-binding post-transcriptional regulator B (LIN28B) feedback loop, reframing sulindac as a precision modulator of oncogenesis.