Though there are currently no direct studies linking FOXO to the NLRP3 inflammasome in periodontitis, research has shown that SIRT1 activation by SRT1720 promotes FOXO1 deacetylation, reduces ROS overproduction, and inhibits NLRP3 inflammasome activation in models of subarachnoid hemorrhage (SAH) [184]. Here, SIRT1 is linked to periodontitis.