Our observation of a sustained increase in Il6 mRNA in ADM uteri at both 1- and 3-month post-adenomyosis induction aligns with clinical reports of elevated IL-6 in the peritoneal fluid and lesional endometrium of patients with adenomyosis and endometriosis (Incognito et al., 2023; Cao et al., 2025). This evidence concerns the gene IL6 and adenomyosis.