HSF1 and Fever: Fever strengthens innate immunity through a cascade of molecular and cellular mechanisms.[21, 67] At the molecular level, fever activates heat shock factor 1 (HSF1), which upregulates HSPs (such as HSP70 and HSP110) to bolster cellular stress resistance and immune adaptation.[63, 68] Moreover, activated HSF1 binds to heat‐shock elements in the non‐classical chemotactic heat shock protein CXCL8 (IL‐8) promoter, driving CXCL8 expression.