Within physiological range (38–40 °C), fever is a defensive response to infection and is well‐documented to enhance host survival following infection.[21, 86, 91, 92, 93] Fever inhibits bacterial proliferation (e.g., Escherichia coli) by disrupting LPS synthesis while amplifying cytokine release (e.g., IL‐1β, IL‐6) from immune cells to enhance pathogen recognition and clearance.[21, 94] Similarly, it suppresses 95% of fungal species, with each 1 °C increase between 30–40 °C reducing fungal growth by an additional 6%.[95] Clinically, Kushimoto et al. This evidence concerns the gene IL1B and infection.