SinceK186 is known to be critical for TREM2–DAP12 interaction andW191 has been potentially linked to Alzheimer’s disease, thissuggests that W191 may play a key role in mediating the interactionbetween TREM2 isoform-219 and DAP12. The gene discussed is TREM2; the disease is early-onset autosomal dominant Alzheimer disease.