TREM2 and early-onset autosomal dominant Alzheimer disease: Given TREM2’s criticalrole in regulating microglial responses to amyloid plaques, includingearly stage plaque seeding and clustering,, structural disruptions such as W191X may mechanistically link alteredmicroglial function to increased Alzheimer’s disease risk.This work focuses on the transmembrane domains of TREM2–DAP12using an 80:20 POPC:cholesterol bilayer, which simplifies the complexlipid environment of microglial membranes.