Measurement of human epidermal growth factor receptor‐2 (HER‐2/neu) levels in serum might play an essential role as a diagnostic/screening marker for breast cancer.[254, 255] Different aptasensor approaches have been applied for the detection of HER‐2257 using electrochemical[257, 258, 259] and optical detection schemes. This evidence concerns the gene ERBB2 and breast carcinoma.