Determination via WB ensued for abundance of principal elements within the PI3K/AKT cascade, demonstrating markedly elevated abundance for AKT1 in conjunction with PI3K amid the ARDS category versus controls (p < 0.0001), whereas abundance for AKT1 together with PI3K proved substantially diminished in the cohort merging ARDS with honeysuckle’s effective constituent relative to the ARDS category (p < 0.0001) (Figure 6F). This evidence concerns the gene PIK3CA and acute respiratory distress syndrome.