TARDBP and amyotrophic lateral sclerosis: Furthermore, we found that exogenous addition of FD-1/-2 to the culture medium attenuated the accumulation of phospho-Tau-S396 and the cytoplasmic mislocalization of transactive response DNA binding protein of 43 ​kDa (TDP-43) in oxidative-stressed ALS-like SOD1-G93A NSC34 ​cells.