ZMYND8 and neoplasm: Functionally, ZMYND8 exhibits context-dependent roles in oncogenesis: it activates oncogenic transcription by recruiting HIF-1α, BRD4, and P-TEFb to augment hypoxia response, lipid metabolism, and cellular proliferation [[21], [22], [23], [24], [25]], yet also represses tumor-suppressive pathways through associations with KDM5C, NuRD, and EZH2 complexes [[26], [27], [28]].