Mieland et al. reported that the HDAC10 inhibitor PZ48 disrupts the MYC-DNA polymerase POLD1 regulatory loop (in which MYC stabilizes POLD1, which in turn increases MYC expression and proliferation), thereby inducing DNA damage and apoptosis in the Ramos BL cell line and in ALL cell lines [86]. This evidence concerns the gene POLD1 and acute lymphoblastic leukemia.