Through whole-genome sequencing of 212 cases of BL (103 EBV-negative and 109 EBV-positive cases), Thomas et al., characterized the IGH::MYC breakpoints in BL and found that EBV-negative BL had significantly more breakpoints attributed to CSR, while EBV-positive BL had significantly more putative SHM-mediated breakpoints. The gene discussed is MYC; the disease is Burkitt lymphoma.