This does not depend on antibody-mediated uptake of opsonised platelets as schistosome-induced thrombocytopenia is maintained in FcRγ-/- mice (S3B Fig), which are in the main resistant to antibody-mediated immune thrombocytopenia (S3C Fig). The gene discussed is FCER1G; the disease is autoimmune thrombocytopenic purpura.