KMT2A and hepatocellular carcinoma: To evaluate pathways regulated by menin-MLL1 in HCC, we performed ontology analysis using the Genomic Regions Annotation Tool (GREAT31) of gene promoters directly bound by both menin and MLL1 proteins and identified enrichment for the tumor necrosis factor alpha (TNF-α), transforming growth factor β (TGF-β), MTORC1, PI3K/AKT, and Hedgehog signaling pathways (Figure 2M; Table S4).