RUNX3 and liver cancer: Notably, in response to prolonged menin inhibition, newly bound NF-YB genes involved in cell proliferation, migration, and invasion in liver cancer (PAK3, SNAI2, AMOT, and RUNX3) showed a significant increase in expression, while NFYB KO reduced their expression (Figures 7C and 7D).41–45 Together, these data demonstrate that at certain menin-bound regions, NF-YB cooperates to support gene activation and gains new significance by continuing to support the expression of specific pathways and by relocalizing to prime new transcriptional targets.