Notably, in response to prolonged menin inhibition, newly bound NF-YB genes involved in cell proliferation, migration, and invasion in liver cancer (PAK3, SNAI2, AMOT, and RUNX3) showed a significant increase in expression, while NFYB KO reduced their expression (Figures 7C and 7D).41–45 Together, these data demonstrate that at certain menin-bound regions, NF-YB cooperates to support gene activation and gains new significance by continuing to support the expression of specific pathways and by relocalizing to prime new transcriptional targets. This evidence concerns the gene PAK3 and liver cancer.