HEXIM2 and insomnia measurement: For Sleeplessness/Insomnia, the top signal was a Bonferroni-significant association with the expression of SMAD5 in blood (eQTLGen; PSMR = 3.25 × 10−11), complemented by pQTL evidence linking it to HEXIM2 (deCODE; PSMR = 3.46 × 10−10).