There are several studies highlighting this characteristic in vitro and in vivo in allergic asthma, allergic rhinitis and atopic dermatitis due to quercetin’s ability to regulate Th1/Th2 balance in a mouse model of asthma, reduce the release of antigen-specific IgE antibodies by B cells and inhibit sneezing in allergic rhinitis [28,29,30,31]. This evidence concerns the gene IGHE and allergic rhinitis.