To understand the interactions between these virion and platelets, HIV-1 pseudovirions were injected into Arf6 (ADP-ribosylation factor 6)-/- mice which led to virion uptake, platelet activation, platelet–leukocyte aggregate formation, and mild thrombocytopenia through IKK and AKT activation [65]. This evidence concerns the gene ARF6 and Thrombocytopenia.