APOH and autoimmune polyendocrinopathy: Further, Naranjo and colleagues found that APS patients, including SLE patients with thrombotic events those positive for B2-CIC, which are circulating immune complexes (CIC) formed by beta-2-glycoprotein-I (B2GP1) and anti-B2GP1 antibodies, had lower platelet count and complement levels than those who were negative, suggesting a greater degree of platelet activation [61].