SOD2 and endometriosis: Oxidative stress resulting from iron and cytokine overflow in endometriosis, particularly in the presence of endometriomas, alters the composition of EVs to incorporate miRNAs and proteins that inhibit NRF2/SOD2 defences, impede mitochondrial renewal mediated by PGC-1α, and disrupt the KITL–KIT and GDF9–BMP15 pathways, which are crucial for cumulus expansion [38].