Similar to a CD4+ T cell, if a CD8+ T cell (while still in the thymus) happens to cross-react with self-peptides presented on mTECs (in complex with the MHC-I molecules), then this self-reactive CD8+ T cell will be converted into a clone of CD8+ TREG cells and involved in suppressing autoimmunity or anticancer immunity (discussed in Section 2.7). Here, CD4 is linked to Autoimmunity.