Given that SIRT1 and Sirtuin 3 (SIRT3) regulate mitochondrial biogenesis and energy homeostasis through Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (PGC-1α), and transcription factor A(TFAM) [22,23,24,25], compounds capable of modulating these targets may provide multifaceted protection against skin aging. This evidence concerns the gene PPARGC1A and skin aging.