Complex 3 (CoQ: cytochrome c-oxidoreductase [69]) deficiency is responsible for fewer mitochondrial disorders [70], although carbonylation of genes like Uqcrc2 (found as downregulated in both untreated CCC and IHF) is a direct response to the stress of Trypanosoma cruzi infection [71]. Here, UQCRC2 is linked to Chagas disease.