The histopathologic subtypes carry differing frequencies of these mutations: The intestinal subtype carried more mutations in APC, TP53, and KRAS, similar to colorectal cancer, but the pancreatobiliary subtype showed a higher incidence of KRAS, TP53, and SMAD4 mutations, similar to pancreatic cancer [13]. This evidence concerns the gene KRAS and familial pancreatic carcinoma.