Regarding the clinical articular involvement in SLE, a statistically significantly higher level of plasma zonulin was observed in patients without articular impairment compared to those with joint manifestations (n = 7, 17.1 ± 4.529 vs. n = 34, 5.604 ± 1.134, p < 0.01; Figure 4). This evidence concerns the gene HP and systemic lupus erythematosus.