To investigate the pro-apoptotic effects of reversine in CML cells, we analyzed caspase-3/7 activity in K-562 and MEG-01 treated with increasing concentrations of reversine (5, 10, 20, and 30 μM) for 24, 48, and 72 h. Here, CASP3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.