Structural variations such as FGFR2 and ROS1 fusions, CDKN2A/B deletions, and amplifications in MET, ERBB2, EGFR, PBX1, c-MET, FGF19, CDK6, and CCND1 have also emerged as key genomic events in iCCA [15,16,17]. Here, MET is linked to infantile convulsions and choreoathetosis.