Zhu et al. (2016) reported that PFK15 treatment decreased Bcl-2 expression without affecting Bax levels in gastric cancer cells, thereby reducing the Bcl-2/Bax ratio, suggesting that the induction of mitochondrial apoptosis likely involves caspase-9 and caspase-3, but not caspase-8 [38]. The gene discussed is CASP8; the disease is gastric cancer.