CGAS and metabolic disease: A high-glucose environment induces intracellular metabolic disorders, leading to reactive oxygen species (ROS) burst [26], accumulation of advanced glycation end products (AGEs) [27], and endoplasmic reticulum stress (ERS) [28] and other pathological changes, and also activates key inflammatory signaling pathways including NF-κB, NLRP3 inflammasome, Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes (cGAS-STING) [29], and so on.