To understand the functional significance of CNPY3, a co-chaperone of GRP94, in the tumor microenvironment, we examined the co-expression of HSP90B1 with co-chaperones, UPR pathway genes, lymphocyte markers, and cytokines using the Oncomine database and found that higher expression of HSP90B1, co-chaperone CNPY3, UPR pathway, and immune-related genes in common solid tumors (Figure 5A). This evidence concerns the gene CNPY3 and neoplasm.