NECTIN1 and neoplasm: HSV-1 has become a commonly used oncolytic viral vector mainly because of its four advantages: a large genome, allowing it to carry ~30 kb of exogenous genes; efficient replication in various tumor cells with a high expression level of the HSV-1 receptor Nectin1; the lysis of tumor cells; and the intrinsic induction of both innate and adaptive antitumor immunity [75].