To mimic the inflammatory milieu present in AD skin we examined the expression profiles of 5-LO/ALOX5 and LTC4S in monocytes and monocyte-derived M-CSF macrophages from AD patients and HVs, following stimulation with the AD-associated cytokines IFNγ, IL-4 and IL-13 [1]. Here, LTC4S is linked to Alzheimer disease.