CD38 and acute lymphoblastic leukemia: In this way, each B-ALL was described as a composite of four cell states as follows: CD34+/CD38− (hematopoietic stem cell–like), CD34+/CD38+ (hematogone-like, stage 1), CD34−/CD38+ (hematogone-like, stages 2 and 3), and CD34−/CD38− (naïve B cell–like).