As BCR::ABL1-like patients cluster with BCR::ABL1-positive patients in our analysis, it may also be possible to predict BCR::ABL1-like B-ALL without testing for specific kinase-activating rearrangements such as IGH::CRLF2, as long as the BCR::ABL1 status is known. This evidence concerns the gene ABL1 and acute lymphoblastic leukemia.