Sun et al. [96] demonstrated that Abrus cantoniensis total flavonoids (ATF) effectively reduced mammary tissue damage and inhibited secretion of inflammatory cytokines including TNF-α, IL-1β, and IL-6 in LPS-induced mastitis models, suppressing the CD14/TLR4/NF-κB/MAPK signaling pathway while enhancing tight junction protein expression in the blood–milk barrier, with intestinal microbiota analysis revealing regulatory effects on microbial composition. This evidence concerns the gene IL1B and mastitis.