Under hypoxic conditions, HIF-1 levels quickly increase and enhance cellular glycolytic capacity by transcriptionally upregulating key glycolytic genes, including HK2, Pfkfb, Pkm2, and Ldha [55,56,57], all of which were upregulated in murine spleens following PCN033 infection based on our transcriptomic data. Here, HK2 is linked to infection.