Functional enrichment revealed a predominant downregulation trend in PG-1 vs. PBS comparison for DEGs enriched in critical immune pathways, including IL-17 signaling pathway, hematopoietic cell lineage, chemokine signaling pathway, Toll-like receptor (TLR) signaling pathway, TNF signaling pathway, JAK-STAT signaling pathway, MAPK signaling pathway, HIF-1 signaling pathway, and NF-κB signaling pathway, directly opposing the pan-upregulation induced by PCN033 infection. The gene discussed is NFKB1; the disease is infection.