CDH2 and neoplasm: Elevated N-cadherin expression facilitates melanoma cell adhesion to dermal fibroblasts and endothelial cells, enhances cell survival and migratory capacity, and activates anti-apoptotic pathways, including AKT/PKB, while upregulating catenin and inhibiting the pro-apoptotic factor BAD, thereby promoting tumor viability and metastatic potential [14].