Epididymo-orchitis is a clinical diagnosis that is primarily made based on presenting history, risk of sexually transmitted infections (STIs), physical examination findings and preliminary investigations such as urethral swab for culture and nucleic acid amplification test (NAAT), mid-stream urine specimen for microscopy and culture, screening for other STIs including blood-borne viruses and blood tests such as full blood count, white cell count and C-reactive protein [115]. The gene discussed is CRP; the disease is sexually transmitted disease.