“With the addition of CpG1018 adjuvant to a single adjuvant, we found that the prepared recombinant herpes zoster vaccine composition consisting of aluminum hydroxide and CpG1018 or SWE adjuvant and CpG1018 could induce higher levels of cytokines, especially IFN-γ production by T cells.” To determine the final adjuvant combination, we performed a dose–response relationship study of SWE/aluminum hydroxide and adjuvant CpG1018. This evidence concerns the gene IFNG and herpes zoster.