Further, the depletion of CD8+ DCs in Batf3−/− mice abrogated the therapeutic activity of the Flagrp170-gp100 vaccine (Figure 5C), which was associated with sharply decreased levels of tumor-infiltrating IFN-γ+CD8+ T cells (Figure 5D), suggesting that the Flagrp170 chaperone vaccine-induced antitumor immune response is mediated by CD8+ DCs. The gene discussed is PMEL; the disease is neoplasm.