GZMB and neoplasm: Another major finding in the current study is that the Flagrp170-based chaperone complex vaccine can mobilize T cells effectively, resulting in high levels of immune infiltration in the tumor compartment and a remodeling of tumor immune niches, evidenced by the significant elevation of a gene signature linked to Th1/Tc1 immunity (e.g., IFN-γ, Granzyme B, IL-12, IL-15) or a T cell inflamed phenotype that can predict patient response to ICIs [8,9,10,11].