PMEL and neoplasm: The FACS analysis further showed that Flagrp170-gp100 vaccination resulted in an increased tumor infiltration by both CD4+ cells and CD8+ cells (Figure 4C), particularly IFNγ-expressing CD8+ T cells (Supplementary Figure S4A), when compared with Grp170-gp100 vaccination, suggesting an improved ability of this chimeric Flagrp170 molecule to mobilize adaptive immune cells infiltrating and remodeling the tumor compartment.