Additionally, we showed that splenocytes or tumor-draining lymph node cells from Flagrp170-gp100 vaccinated mice produced significantly higher levels of INF-γ upon stimulation with gp10025–33 peptide than those from the Flagrp170-gp100 vaccinated mice (Figure 4D), suggesting a superior Flagrp170 activity in inducing a systemic antigen-specific T cell response. The gene discussed is PMEL; the disease is neoplasm.