Optic neuropathies (ON) represent a clinically heterogeneous group of disorders that result in varying degrees of visual impairment and disability, with etiologies ranging from glaucomatous, ischemic, isolated inflammatory episodes to systemic neuroimmunology diseases, such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) [1,2,3]. The gene discussed is MOG; the disease is myeloid sarcoma.