Moreover, the HTN–DM group was characterized by the lowest M-ACE (median 25 points) (Figure 2C) (vs. HC p < 0.000 and vs. HTN p = 0.006) and MMSE (median 27 points) (Figure 2D) (vs. HC p < 0.000 and vs. HTN p = 0.002). The gene discussed is ACE; the disease is diabetes mellitus.