TNNC1 and cardiomyopathy: If it turns out that TNNC1 has demonstrable roles in cardiomyocyte nuclei, it might help to explain why human TNNC1-linked cardiomyopathies are typically associated with a relatively poor prognosis [102,103] and why some pathogenic variants in TNNC1 cannot be explained by perturbed myofilament mechanical properties [104].