This notion is further supported by evidence demonstrating that β-blocker therapy in patients with dilated cardiomyopathy (DCM) can partially reverse this maladaptive transcriptional pattern by upregulating MYH6 and downregulating MYH7, an adjustment associated with improved left ventricular ejection fraction [11,12]. This evidence concerns the gene MYH7 and familial dilated cardiomyopathy.