TTR and amyloidosis: Additionally, recent clinical data indicate that among patients over 75 with confirmed ATTR-wt, 75% were classified as frail based on the G8 screening tool [30] and another study based on autopsy data demonstrated that TTR amyloidosis occurs in the left ventricular myocardium in 32% of patients who are older than 75 years old with heart failure with preserved ejection fraction (HFpEF) [31], highlighting the intersection between aging, frailty, and disease burden in this population.