Furthermore, renal failure can accelerate CAD by the renin–angiotensin–aldosterone system (RAAS) [44,45], pre-calcification pathway [38], advanced glycation end-products (sRAGE) [46], and intestinal microbiome [47] and IR, promoting the progression of coronary atherosclerosis or acute cardiovascular events [38]. The gene discussed is REN; the disease is acute kidney injury.