Albumin showed a stepwise decline across the spectrum of HE, from 3.00 [2.80–3.40] g/dL in HE1 to 2.60 [2.20–2.70] g/dL in HE2 and 2.50 [2.35–2.50] g/dL in HE3 (p < 0.001, Kruskal–Wallis test). The gene discussed is ALB; the disease is hereditary elliptocytosis.