The comprehensive network demonstrated three-tier pharmacological correlations, including Anti-infective mechanisms: Pathogen-specific pathways (Salmonella infection, Legionellosis, Shigellosis) intersected with immune regulation pathways (NOD-like receptor signaling, C-type lectin receptor signaling), suggesting broad-spectrum antimicrobial potential through dual pathogen-targeting and host immunity modulation. This evidence concerns the gene CLEC4D and legionellosis.