In this study, the mQTLs at FADS1, each with high minor allele frequency, between 0.33 and 0.42, displayed GxD interaction with SSB intake and total carbohydrate intake on T2D risk, and T2D-related phenotypes, i.e., glucose and HOMA-IR, in participants who were not using anti-diabetes medication. Here, FADS1 is linked to type 2 diabetes mellitus.