Abbreviations: HOMA-IR: Homeostatic Model Assessment for Insulin Resistance; kPa: kilopascal; SAT: subcutaneous adipose tissue; VAT: visceral adipose tissue; IQR: interquartile range; BIC: bictegravir; DTG: dolutegravir; TGO or AST: alanine aminotransferase; TGP or ALT: aspartate transaminase; GGT: gamma-glutamyl transferase; PA: alkaline phosphatase; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein. The gene discussed is GPT; the disease is Insulin resistance.