Finally, Wang et al. (2021) demonstrated cross-talk or dynamic interplay between immunotherapy and sex hormone levels, with anti-PD-L1 treatment decreasing serum levels of both testosterone and estradiol in male but not female mice models of colon cancer, likely through the disturbance of lipid metabolism and inflammation in the testes of male mice [47]. The gene discussed is CD274; the disease is malignant colon neoplasm.