SOAT1 and neoplasm: Multiple tumor-intrinsic mechanisms have been shown to contribute to T cell lymphomagenesis, including the acquisition of genomic alterations in the JAK-STAT signaling pathways, T cell receptor (TCR), T cell activation-related genes (CD28, CD40, PI3K-AKT, AP-1), and, in some subtypes, the RHOA pathway and epigenetic modifier genes.