Similar alterations have also been reported in extranodal NK/T cell lymphomas (ENKTL), where mutations in HLA-A, β2M, and TAP1 correlate with more advanced disease stage [12], while approximately 50% of cases of adult T cell leukemia/lymphoma (ATLL) also harbor HLA Class 1 and/or β2M mutations [13,14]. This evidence concerns the gene B2M and adult T-cell leukemia/lymphoma.