CD30 is a membrane glycoprotein from the tumor necrosis factor (TNF) receptor family and is frequently overexpressed in classical Hodgkin lymphoma (HL) and ALCL [153,154], with expression observed in 93–100% of cases in both ALK-positive and ALK-negative ALCL tumors [139,155]. The gene discussed is ALK; the disease is classic Hodgkin lymphoma.