For asthma and COPD, one SNP rs11168048 located at 5q32 (harboring HTR4, FBXO38, and SPINK7) and two SNPs rs2122190 located at 5q23.1 (harboring PRR16) and rs6860087 located at 5q32 (harboring HTR4) were identified (Table S2). This evidence concerns the gene SPINK7 and chronic obstructive pulmonary disease.